DRUG DELIVERY SYSTEMS COMPRISING SOLID SOLUTIONS OF WEAKLY BASIC DRUGS
摘要
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 µg/mL at pH 6.8.
申请公布号
WO2008027993(A3)
申请公布日期
2008.09.12
申请号
WO2007US77153
申请日期
2007.08.29
申请人
EURAND, INC.;VENKATESH, GOPI;BOLTRI, LUIGI;COLOMBO, ITALO;LAI, JIN-WANG;FLABIANI, FLAVIO;MAPELLI, LUIGI
发明人
VENKATESH, GOPI;BOLTRI, LUIGI;COLOMBO, ITALO;LAI, JIN-WANG;FLABIANI, FLAVIO;MAPELLI, LUIGI