发明名称 |
SUGAR CHAIN-CONTAINING ALBUMIN, PRODUCTION METHOD THEREOF AND USE THEREOF |
摘要 |
Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.
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申请公布号 |
CA2611540(A1) |
申请公布日期 |
2009.05.09 |
申请号 |
CA20072611540 |
申请日期 |
2007.11.09 |
申请人 |
NIPRO CORPORATION |
发明人 |
NAKAJOU, KEISUKE;KATAYAMA, NAOHISA;KAI, TOSHIYA;OTAGIRI, MASAKI |
分类号 |
C12N15/14;A61K38/38;A61K47/42;A61K47/48;C07K14/76;C07K14/765;C12N15/12;C12N15/79;C12N15/81 |
主分类号 |
C12N15/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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