Oxidized lipid compounds and uses thereof

摘要

Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.

主权项

1. A compound having a formula:or a stereoisomer, an optical isomer, an enantiomer, a racemic mixture, or a stereoisomeric mixture thereof, or a pharmaceutically acceptable salt thereof, wherein:
(i) A1, A2 and A3 are each independently selected from the group consisting of O and S; (ii) R1 is selected from the group consisting of eicosanyl and (2-octyl)dodecyl; (iii) R2 is wherein X is a C1-25 alkyl, Y is selected from the group consisting of:  —OH, —H, alkyl, alkoxy, halogen, acetoxy and an aromatic functional group; and
Z is selected from the group consisting of: wherein R′ is C1-4 alkyl; and (iv) R3 is selected from the group consisting of H, acyl, alkyl, phosphate, phosphocholine, phosphoethanolamine, phosphoethanolamine-N-glutaric acid, phosphoserine, and phosphoinositol.