Controlled release antimicrobial compositions and methods for the treatment of otic disorders

摘要

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

主权项

1. A method of treating middle ear effusion in a pediatric patient with otitis media undergoing tympanostomy tube placement, the method comprising intratympanically administering to the pediatric patient a composition comprising poloxamer 407 and a therapeutically effective amount of multiparticulate and non-microencapsulated ciprofloxacin, wherein the composition provides a sustained release of ciprofloxacin in the ear for a period of at least 5 days after a single intratympanic administration; and wherein the composition comprises from about 10 wt % to about 20 wt % poloxamer 407.