Implantable biomaterial and a method of producing same

摘要

The present invention relates to an implantable biomaterial and methods of producing same. In particular, the present invention relates to a method for producing an implantable biomaterial comprising (a) exposing a biomaterial to an alcohol-containing solution for at least 24 hours.

主权项

1. A method for producing a collagen containing calcification resistant implantable biomaterial comprising:
(a) exposing a collagen containing material to a solution containing one or more C1-C6 water soluble lower alcohols at a temperature of about 5° C. for at least 24 hours; (b) removing said collagen containing material from said solution in step (a) and exposing said material to a cross-linking agent; and (c) removing said collagen containing material from said cross-linking agent in step (b) and exposing said material to a buffer-free acidic solution containing an aminocarboxylic acid at a temperature between 5° C. and 55° C. for at least 6 hours to produce said calcification resistant implantable biomaterial; wherein the collagen containing material used in step (a) has not been previously cross-linked.