Modifying polymer properties with penetrants in the fabrication of bioresorbable scaffolds

摘要

Methods of fabricating a bioresorbable polymer scaffold are disclosed including a step of inducing crystallization in a bioresorbable polymer construct through exposure to a liquid penetrant.

主权项

1. A method of fabricating a bioresorbable stent scaffold comprising:
providing a tube made of a bioresorbable polymer comprising amorphous poly (L-lactide); exposing the tube to a fluid for a period of time to reach a % uptake of saturation, wherein the % uptake of saturation is a maximum % uptake of the fluid of the tube, wherein the fluid is methanol, wherein the fluid is absorbed into the bioresorbable polymer and increases a flexibility of the bioresorbable polymer, wherein the fluid is absorbed without dissolving the polymer; radially expanding the exposed tube comprising the absorbed fluid from a first diameter to a second diameter; and fabricating a scaffold having a pattern of interconnected struts from the radially expanded tube.