| 摘要 |
PROBLEM TO BE SOLVED: To provide an alternative, relatively simple, economical and commercially feasible process for the synthesis of tiotropium bromide crystalline forms with commercially acceptable yields, chemical purity and high polymorphic purity and polymorphic stability.SOLUTION: The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising the anhydrous tiotropium bromide, and uses of the compositions. |
