发明名称 |
ANTI-HER2 GLYCOANTIBODIES AND USES THEREOF |
摘要 |
The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered. |
申请公布号 |
WO2015184002(A1) |
申请公布日期 |
2015.12.03 |
申请号 |
WO2015US32738 |
申请日期 |
2015.05.27 |
申请人 |
ACADEMIA SINICA;WONG, CHI-HUEY |
发明人 |
WONG, CHI-HUEY;WU, CHUNG-YI |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|