Isolating Biological Modulators from Biodiverse Gene Fragment Libraries

摘要

The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of:
(i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and(ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.

主权项

1. A gene fragment expression library comprising a plurality of different nucleotide sequences from a plurality of biodiverse organisms each having a sequenced genome and wherein the organisms are microorganisms and/or eukaryotes having compact genomes.