| 发明名称 |
SECOAPORPHINE ALKALOID DERIVATIVE FOR ACTIVATING AMP-DEPENDENT PROTEIN KINASE |
| 摘要 |
The present invention provides a method for activating the AMP-dependent protein kinase (AMPK) in a subject comprising administering the subject with a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having the general Formula I, preferably 1,10-dihydroxyaporphine. The pharmaceutical composition is able to activate AMPK, and thus is effective in the regulation of cell growth and metabolism, and the treatment of AMPK associated diseases. |
| 申请公布号 |
US2015342908(A1) |
申请公布日期 |
2015.12.03 |
| 申请号 |
US201414492652 |
申请日期 |
2014.09.22 |
| 申请人 |
ZIH YUAN TANG Biotechnology Co., Ltd |
发明人 |
Lee Shoei-Sheng;Su Ming-Jai;Yeh Chi-Huan;Tsai Cheng-Yen;Ruan Chi-Tun;Hsu Chao-Min |
| 分类号 |
A61K31/137 |
主分类号 |
A61K31/137 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for activating the AMP-dependent protein kinase (AMPK) in a subject comprising administering the subject with a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having the general Formula I or a pharmaceutically acceptable salt:wherein R1, R2 and R3 are each independently H or alkyl group; R4 is H, alkyl, allyl (—CH2CHCH2) or benzyl group. |
| 地址 |
Taipei City TW |
