NOVEL HETEROCYCLIC DERIVATIVES

摘要

The invention relates to novel heterocyclic compounds of the formula;;in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.

主权项

1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein X represents CH; R1 represents wherein
R18 and R22 independently represent hydrogen, halogen, hydroxy or hydroxy-C1-3alkyl-;R19 and R21 independently represent hydrogen, amino, hydroxy, carboxy, C1-3alkoxy, amino-C1-3alkyl-, C1-3alkyl-C(═O)—NH—, C1-3alkyl-S(═O)m—NH— or hydroxy-C1-3alkyl-;m represents 0, 1 or 2;R20 represents hydrogen, halogen or C1-3alkoxy; or R1 is selected from the group consisting of wherein
R23 represents hydrogen or methyl;R24 represents hydrogen, oxo or C1-3alkyl; R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 and R17 independently represent hydrogen or methyl; or R2 and R8 together form an ethylene bridge; or R2 and R6 together form a methylene bridge; or R12 and R14 together form an ethylene bridge; and Y represents O, CHR25 or CR26R27 whereinR25 represents hydroxy or C1-3alkoxy; andR26 and R27 independently represent hydrogen or halogen; with the proviso that the compound of formula (I) is other than 2,6-di-morpholin-4-yl-8-phenyl-9H-purine.