METHODS OF TREATMENT OF HISTAMINE H-4 RECEPTOR-RELATED PRURITUS ASSOCIATED WITH NERVE DISORDERS

摘要

The methods disclosed herein relate to the treatment of histamine H-4-related pruritus associated with nerve disorders, by administering a combined histamine H-1 and H-4 receptor inhibitor, specifically RS-norketotifen or a pharmaceutically acceptable salt thereof. Potentiated antipruritic activity by simultaneous inhibition of histamine H-1 receptors and histamine H-4 receptors are described.

主权项

1. A method of treating a human patient suffering from histamine H-4 receptor related pruritus associated with a nerve disorder, comprising
orally administering to said human patient a therapeutically effective amount of RS-norketotifen or a pharmaceutically acceptable salt thereof, thereby reducing pruritic symptoms associated with the nerve disorder in the human patient.