ANTIBODY BINDING SPECIFICALLY TO HUMAN AND MOUSE L1CAM PROTEIN, AND USE THEREFOR

摘要

The present invention relates to a novel antibody specifically binding to human and mouse L1CAM, and more particularly, to an antibody binding to both human and mouse L1CAM with high affinity, which is prepared by modifying a sequence of an L1 cell adhesion molecule (L1CAM)-specific antibody comprising a heavy-chain variable region of SEQ ID NO. 1 and a light-chain variable region of SEQ ID NO. 5, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide, a transformant introduced with the vector, a pharmaceutical composition for preventing or treating cancer comprising the antibody, a method for treating cancer using the antibody, a composition for diagnosing cancer comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for providing information for cancer diagnosis using the antibody, and an antibody-drug conjugate prepared by conjugating a drug to the antibody.

主权项

1. An antibody binding to human L1 cell adhesion molecule (L1CAM) protein, comprising:
a heavy-chain variable region comprising (i) a heavy chain CDR1 of SEQ ID NO. 2; (ii) a heavy chain CDR2 of SEQ ID NO. 9 or a heavy chain CDR2 of SEQ ID NO. 9 except for a substitution of glutamic acid for aspartic acid as an amino acid at position 5; and (iii) a heavy chain CDR3 of SEQ ID NO. 10; and a light-chain variable region comprising (iv) a light chain CDR1 of SEQ ID NO. 6 or a light chain CDR1 of SEQ ID NO. 6 except for a substitution of serine for isoleucine as an amino acid at position 8; (v) a light chain CDR2 of SEQ ID NO. 7; and (vi) a light chain CDR3 of SEQ ID NO. 11 or a light chain CDR3 of SEQ ID NO. 15.