发明名称 |
CANCER STEM CELL-SPECIFIC MOLECULE |
摘要 |
An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker Lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective of the present invention is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients. The present inventors discovered that highly pure large intestine cancer stem cells (CSC) can be obtained in a large quantity, and identified the two types of conditions of large intestine CSCs distinguishable through Lgr5 expression. Moreover, the present inventors discovered that an antibody against a cell membrane molecule specifically expressed in said cancer stem cells can damage said cells. |
申请公布号 |
EP2772268(A4) |
申请公布日期 |
2015.12.02 |
申请号 |
EP20120844389 |
申请日期 |
2012.10.26 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
YAMAZAKI, TATSUMI;OKABE, HISAFUMI;KOBAYASHI, SHINTA;WATANABE, TAKESHI;MATSUBARA, KOICHI;NATORI, OSAMU;KATO, ATSUHIKO;SUZUKI, MASAMI |
分类号 |
A61K39/395;A61K39/39;C07K14/51;C07K16/30;C12Q1/68;G01N33/15;G01N33/50;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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