发明名称 |
ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY |
摘要 |
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. |
申请公布号 |
EP2275443(B1) |
申请公布日期 |
2015.12.02 |
申请号 |
EP20090729337 |
申请日期 |
2009.04.10 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;ISHII, SHINYA;MAEDA, ATSUHIKO;NAKAI, TAKASHI |
分类号 |
C07K16/28;A61K39/00;C07K16/24;C12N15/10;G01N33/68 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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