发明名称 |
DUAL VECTOR FOR INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS |
摘要 |
The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed. |
申请公布号 |
EP2949208(A1) |
申请公布日期 |
2015.12.02 |
申请号 |
EP20150166660 |
申请日期 |
2010.05.26 |
申请人 |
CALIMMUNE INC. |
发明人 |
BRETON, LOUIS RANDALL;CHEN, IRVIN;AN, DONG SUNG;SYMONDS, GEOFFREY P.;BOYD, MAUREEN;MILLINGTON, MICHELLE L. |
分类号 |
A01K67/027;A61K35/28;A61K48/00;C07K14/00;C07K14/16;C07K14/47;C12N9/90;C12N15/113;C12N15/85;C12N15/867 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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