| 发明名称 | A3 adenosine receptor ligands for modulation of pigmentation | ||
| 摘要 | The present invention relates to compositions and methods for modulating melanin production, secretion and/or accumulation in human skin cells. In particular, the present invention relates to the use of A3 adenosine receptor antagonists in compositions and methods for the treatment and amelioration of hyper-pigmentation conditions and for the lightening of skin, and to the use of A3 adenosine receptor agonists in compositions and methods for the treatment and amelioration of hypo-pigmentation conditions and for the tanning of skin. | ||
| 申请公布号 | US9199102(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201013386339 | 申请日期 | 2010.07.20 |
| 申请人 | ORADIN PHARMACEUTICAL LTD. | 发明人 | Madi Lea Levana;Korenstein Rafi |
| 分类号 | A61K8/00;A61Q19/04;A61K8/49;A61K8/60;A61K31/4418;A61K31/7076;A61Q19/02 | 主分类号 | A61K8/00 |
| 代理机构 | Rothwell, Figg, Ernst & Manbeck, P.C. | 代理人 | Rothwell, Figg, Ernst & Manbeck, P.C. |
| 主权项 | 1. A method for increasing melanin production, secretion, accumulation, or a combination thereof, comprising contacting a skin cell with an effective amount of an A3 adenosine receptor agonist, wherein the A3 adenosine receptor agonist is N6-substituted-adenosine-5′-uronamide. | ||
| 地址 | Tel Aviv IL | ||