| 发明名称 |
Lyophilized preparation of botulinum toxin |
| 摘要 |
There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention can maintain an activity of botulinum toxin, and also exhibit excellent long-term storage stability even under conditions of high temperature, which may occur when botulinum toxin is stored, delivered, and processed. |
| 申请公布号 |
US9198958(B2) |
申请公布日期 |
2015.12.01 |
| 申请号 |
US201414533735 |
申请日期 |
2014.11.05 |
| 申请人 |
Medy-Tox Inc. |
发明人 |
Jung Hyun Ho;Yang Gi Hyeok;Rhee Chang Hoon;Kim Hack Woo;Kim Sung Bum;Baek Seung Hwan |
| 分类号 |
A61K38/46;A61K38/43;A61K38/48;A61K9/19;A61K47/02;A61K47/18;A61K47/22;A61K47/26;A61K47/00;A61K47/20 |
主分类号 |
A61K38/46 |
| 代理机构 |
|
代理人 |
Chan Ted A. |
| 主权项 |
1. A pharmaceutical lyophilized preparation comprising:
botulinum toxin, polysorbate, and methionine; and one or more components selected from the group consisting of sugar, sugar alcohol, and an ionic compound,wherein the preparation is free of albumin, andwherein stability of the botulinum toxin is maintained for at least 30 days at 40° C. and 70% relative humidity. |
| 地址 |
KR |
