anticorpos monoclonais seletivos anti-hepcidina-25, seus usos, bem como método e kit para quantificar a quantidade de proteína hepcidina-25 em uma amostra de tecido ou fluido biológico

摘要

Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.