发明名称 |
High activity growth factor mutants |
摘要 |
The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity. |
申请公布号 |
US9200048(B2) |
申请公布日期 |
2015.12.01 |
申请号 |
US201414182604 |
申请日期 |
2014.02.18 |
申请人 |
Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH |
发明人 |
Pohl Jens;Ploeger Frank;Kruse Michael |
分类号 |
C07K14/495;C07K14/475;A61K38/00 |
主分类号 |
C07K14/495 |
代理机构 |
Rothwell, Figg, Ernst & Manbeck, P.C. |
代理人 |
Rothwell, Figg, Ernst & Manbeck, P.C. |
主权项 |
1. A method for promoting cartilage growth in a patient in need thereof, comprising administering to the patient an effective amount of a recombinant protein comprising an amino acid sequence at least 75% identical to the 102 amino acid cysteine-knot domain of GDF-5 or a fragment of said recombinant protein, wherein
a) the amino acid at the position corresponding to methionine 453 (M453) of human wild-type GDF-5 (SEQ ID NO: 1) is alanine, valine or isoleucine, and/or b) the amino acid at the position corresponding to methionine 456 (M456) of human wild-type GDF-5 (SEQ ID NO: 1) is alanine, valine or isoleucine,and further wherein the recombinant protein or the fragment of said recombinant protein has an improved biological activity of at least 120% when compared to the mature GDF-5 protein. |
地址 |
Heidelberg DE |