Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith

摘要

A substantially purified substance having the properties of a bacterial microcin methionine analog, methionine synthesis inhibitor, tRNA-methionine synthase inhibitors or methionine competitive inhibitor capable of inhibiting tumor cell growth without inhibiting the growth of normal cells or treating neoplastic diseases, and may be used alone or in combination with other anti-cancer agents. The purified substance may also have anti-hyperhomocysteineuria and/or anti-infective properties, such as antifungal activity. The purified substance can be safely administered to animals including humans for the treatment of neoplastic, hyperhomocysteinemia and/or infectious diseases for the treatment of those diseases.

主权项

1. A method of treating an animal, comprising administering an effective dose of at least one substantially purified, pharmaceutically acceptable microcin methionine analogue or microcin methionine synthesis inhibitor except microcin 15m or microcin M15 or a microcin from E. coli LP15, to an animal having at least one of a tumor, hyperhomocysteinemia, and an infectious disease, in an effective amount to thereby respectively inhibit tumor growth, treat hyperhomocysteinemia, or treat the infectious disease.