| 发明名称 |
Single ifn- β fused to mutated lgg fc fragment |
| 摘要 |
The invention relates to a protein comprising a single IFN-beta fused to a mutated IgG Fc domain containing two subunits, wherein the first subunit comprises a mutated IgG Fc arm not linked to a IFN-beta protein, and the second subunit comprises a mutated IgG Fc arm linked to a single IFN-beta protein, and wherein said mutated IgG Fc domain is an immunoglobulin gamma-1 Fc domain and wherein said Fc domain comprises at least five mutations. |
| 申请公布号 |
IL204948(A) |
申请公布日期 |
2015.11.30 |
| 申请号 |
IL20100204948 |
申请日期 |
2010.04.08 |
| 申请人 |
MERCK SERONO S.A.;PETER HJELMSTROM;MARKUS IMHOF;GEORGE FEGER;NIGEL JENKINS;PHILLIPPE DUPRAZ;CHRISTINE POWER;LAURENT MAGENANT;PHILLIPPE CHATELLARD;RENATA PANKIEWICZ;VINCENT DECHAVANNE |
发明人 |
PETER HJELMSTROM;MARKUS IMHOF;GEORGE FEGER;NIGEL JENKINS;PHILLIPPE DUPRAZ;CHRISTINE POWER;LAURENT MAGENANT;PHILLIPPE CHATELLARD;RENATA PANKIEWICZ;VINCENT DECHAVANNE |
| 分类号 |
A61K;A61P;C07K;C12N |
主分类号 |
A61K |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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