| 摘要 |
The disclosure relates to a method for preparing and purifying noribogaine which method comprises: (a) covalently attaching voacangine to a solid support via the indole nitrogen of voacangine so as to form a suspension of solid supports having voacangine bound thereto; (b) converting voacangine to 12-hydroxyibogamine-18-carboxylic acid methyl ester, 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt thereof under conditions wherein the level of voacangine bound to the solid support is less than 0.1 weight percent; (c) cleaving and recovering 12-hydroxyibogamine-18-carboxylic acid methyl ester, 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt thereof from the solid support; (d) converting the 12-hydroxyibogamine-18-carboxylic acid methyl ester, 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt thereof to noribogaine; and (e) isolating and purifying noribogaine. |
