| 摘要 |
The present invention relates to a method for producing a glioblastoma mouse model, comprising the steps of: (a) dividing a glioblastoma tissue, isolated from a patient, into 4 or more sections, and collecting one or more pieces from each of the sections; (b) dissociating a mixture of the collected pieces into glioblastoma cells as single cells; and (c) orthotopically transplanting a graft sample, which contains the glioblastoma cells obtained in step (b), into the brain of an immunodeficient mouse. The present invention also relates to a mouse model produced by the method, a method of screening a glioblastoma therapeutic agent using the mouse model, and a method of providing information for selection of a patient-specific glioblastoma therapy using the mouse model. The glioblastoma mouse model according to the present invention shows the same genetic, morphological and pathological characteristics as those of the parental tumor, and thus it makes possible to screen a patient-specific glioblastoma therapeutic agent or select a safer and more effective patient-specific glioblastoma therapy. |
