Methods and Compositions for Treating Malignancies with Dendritic Cells

摘要

This invention provides methods and compositions for the treatment and/or prevention of cancer, including solid malignancies and hematologic malignancies. In particular, the present invention relates to immunotherapy using antigen-presenting cells loaded with tumor associated peptide antigens (TAPAs). If a subject expresses at least one tumor-associated antigen, the subject can be treated by antigen-presenting cells (e.g., dendritic cells) loaded with at least one tumor-associated peptide antigen derived from the tumor-associated antigen (s) expressed by the subject. This personalized immunotherapy induces or enhances immune responses to cells that express tumor-associated antigen(s).

主权项

1. A method of treating and/or preventing cancer in a subject, the method comprising the steps of:
(a) determining whether the subject expresses at least one tumor-associated antigen, wherein the tumor-associated antigen comprises Sp17, Ropporin, AKAP-4, PTTG1, Span-xb, Her-2/neu, HM1.24, NY-ESO-1, MAGE-1 or combinations thereof; (b) loading antigen-presenting cells with at least one tumor-associated peptide antigen (TAPA) derived from at least one tumor-associated antigen expressed by the subject; and (c) administering the antigen-presenting cells from step (b) to the subject.