Styrenyl derivative compounds for treating ophthalmic diseases and disorders

摘要

DcumntK.23-127/2012 The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions 5 comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. WO 2008/131368 PCT/US2008/061073 A 25 mglkg Compound A E 0 10mgkg Compound i o e 8o*2a 00 'ig *d eControl o 60 0 Bleached Control 40' 20< 0 i 0 4 8 12 16 20 24 Hours post oral dose Fig. 1 200- . Compound B EI* Compound A o 150' * Compound 25 V Compound 1 -100 .3 M 2hr Recovery 5 Dark 0 o Light -4 3 -2 -1 0 1 2 Ig (mglkg) Fig. 2