CCN3 AND CCN3 PEPTIDES AND ANALOGS THEREOF FOR THERAPEUTIC USE

摘要

The present invention provides a method for treating a human patient with a pathology by administering to the subject an effective amount of an agent selected from the group of: native full-length CCN3 proteins; analog CCN3 full-length proteins with native cysteine residues substituted by a replacement amino acid; CCNp native peptide fragments having from about 12 to about 20 amino acids; analog CCNp peptide fragments with native cysteine residues substituted with a replacement amino acid; and combinations thereof.

主权项

1. A method for preventing and or treating fatty liver disease, steatosis, liver fibrosis, and liver cancer in a subject in need thereof comprising:
administering to the subject an effective amount of a native CCNp38 peptide fragment (SEQ. ID. Nos. 49, 50) or an analog CCNp38 peptide fragment with native cysteine residues substituted with a replacement amino acid (SEQ. ID. Nos. 38, 56, 57, 58, and 60).