| 发明名称 |
LILRB2 AND NOTCH-MEDIATED EXPANSION OF HEMATOPOIETIC PRECURSOR CELLS |
| 摘要 |
The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders. |
| 申请公布号 |
CA2948871(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
CA20152948871 |
申请日期 |
2015.05.21 |
| 申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER;BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ZHENG, JUNKE;ZHANG, CHENGCHENG;DENG, MI;LU, ZHIGANG;BERNSTEIN, IRWIN D. |
| 分类号 |
C12N5/0789;A61K35/28;C07K16/28;C07K19/00;C12N5/00;C12N5/071;C12N5/0735;C12N5/078;C12N5/10;C12N15/62;C12Q1/68 |
主分类号 |
C12N5/0789 |
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