Processes of making and crystalline forms of a MDM2 inhibitor
摘要
The present invention provides processes for making 2-((3R,5R,6S)-5-(3- chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3- methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
申请公布号
AU2014278428(A1)
申请公布日期
2015.11.26
申请号
AU20140278428
申请日期
2014.06.09
申请人
AMGEN INC.
发明人
BIO, MATTHEW;CAILLE, SEBASTIEN;COCHRAN, BRIAN;FANG, YUANQING;FOX, BRIAN M.;LUCAS, BRIAN S.;MCGEE, LAWRENCE R.;VOUNATSOS, FILISATY;WIEDEMANN, SEAN;WORTMAN, SARAH