System and method for early detection of mild traumatic brain injury

摘要

A wireless system and methods for non-invasive detection of brain injury that includes a detection device for reliable monitoring and analyzing of sleep movement in comparison with normal sleep movement architecture to identify dampened sleep movement patterns indicative of brain injury.

主权项

1. A method of testing a subject for brain injury comprising the steps of:
(a) monitoring the sleep movements of a subject using movement sensors operable at a sampling rate of at least 10 Hz to generate a plurality of temporally-associated data signals relating to sleep movements; (b) parsing the data at least once into a plurality of bins of defined temporal duration of 60 seconds or less, and determining an average value for each bin to differentiate bouts of micro-structural movements from bouts of quiescence and bouts of macro-structural movements; and identifying a period of 1-3 hours during which the data signals include no movements indicative of frank awakenings, and wherein step (b) includes the following sub-steps applied to the data of said period:
(b1) calculate a grand mean value for the data generated in step (a);(b2) compare each bin to the grand mean and assigning a zero binary value when the bin is less than the grand mean and a unity binary value when the bin is greater than the grand mean;(b3) set movement bout onset/offset criteria; and(b4) calculate mean and maximum durations for spontaneous micro-structural movement bouts, (c) comparing the values for bouts of micro-structural movements to a threshold value that is indicative of brain injury; and (d) assigning a determination of brain injury according to the outcome of the comparison.