| 发明名称 | Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors | ||
| 摘要 | This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein ; Q, J, L and Z are as defined in the specification. | ||
| 申请公布号 | US9193749(B2) | 申请公布日期 | 2015.11.24 |
| 申请号 | US201313767478 | 申请日期 | 2013.02.14 |
| 申请人 | Forum Pharmaceuticals, Inc.;MethylGene, Inc. | 发明人 | Deziel Robert;Leit Silvana;Beaulieu Patrick;Chantigny Yves Andre;Mancuso John;Tessier Pierre;Shapiro Gideon;Chesworth Richard;Smil David |
| 分类号 | C07D491/00;C07H13/10;C07D209/02;C07D209/08;C07D209/52;C07D209/94;C07D221/12;C07D223/16;C07D223/20;C07D223/22;C07D223/26;C07D223/28;C07D225/08;C07D239/28;C07D239/34;C07D239/42;C07D243/24;C07D243/38;C07D265/38;C07D267/14;C07D267/18;C07D267/20;C07D279/22;C07D279/26;C07D285/36;C07D291/08;C07D313/12;C07D401/14;C07D403/04;C07D403/14;C07D413/06;C07D413/12;C07D471/04;C07D471/08;C07D487/04;C07D487/08;C07D487/14;C07D491/08;C07D495/04;C07D498/04;C07D513/04;C07D281/16;C07D295/155 | 主分类号 | C07D491/00 |
| 代理机构 | Jones Day | 代理人 | Jones Day |
| 主权项 | 1. A method of inhibiting histone deacetylase, comprising contacting the histone deacetylase with a pharmaceutical composition comprising: i) (Z)-4-(dibenzo[b,f][1,4]oxazepin-11-yl)-N-hydroxybenzamide, or a pharmaceutically acceptable salt thereof; and ii) a pharmaceutically acceptable carrier, excipient, or diluent. | ||
| 地址 | Waltham MA US | ||