| 发明名称 | Method of treating cardiac arrhythmia with long acting atrial natriuretic peptide(LA-ANP) | ||
| 摘要 | Materials and Methods related to making and using natriuretic polypeptides having a mutation that results in an extended carboxy terminus. | ||
| 申请公布号 | US9193777(B2) | 申请公布日期 | 2015.11.24 |
| 申请号 | US201313889865 | 申请日期 | 2013.05.08 |
| 申请人 | Mayo Foundation for Medical Education and Research;University of Iowa Research Foundation | 发明人 | Burnett, Jr. John C.;Olson Timothy M.;Zingman Leonid V.;Hodgson-Zingman Denice Marie |
| 分类号 | C07K14/58;A61K38/22 | 主分类号 | C07K14/58 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method for treating a cardiac arrhythmia in a mammal in need thereof, comprising administering to the mammal an effective amount of a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:6, with two amino acid additions, subtractions, or substitutions, wherein the polypeptide has a length between 17 and 45 amino acids and has natriuretic activity. | ||
| 地址 | Rochester MN US | ||