| 主权项 |
1. A method of modulation of S1P receptor activity and/or expression by the administration of an effective amount of a compound of formula (II) or a stereoisomer and/or isotopic form or a pharmaceutically acceptable salt or derivative thereof, to a subject in need thereof wherein B′ is a five-membered heterocyclic ring selected from one of the following: the asterisks indicating the attachment within formula (II); G represents R is selected from hydrogen, deuterium, alkylamino, CH2OH, alkoxy, a C1-5 alkyl chain optionally containing one or more of deuterium, O, NR′R″, S, and halogen, heterocycle, amide, sulphonamide, COOH, —OPO3H2, and —PO3H2,represents an optional bridging group;
A ring is phenyl or pyridinyl; R2 independently is selected from halogen, hydrogen, deuterium, CN, amino, alkylamino, alkoxy, CF3, and a C1-4 alkyl chain optionally containing one or more of deuterium, OH, NR′R″, S, SO, SO2, a carbon-carbon double bond, a carbon-carbon triple bond, a carbon-heteroatom double bond, a carbon-hetero atom triple bond, carbocycle, heterocycle, amide, and sulphonamide; J and D each are independently selected from hydrogen, deuterium, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, halogen, amino, hydroxy, cyano, aryl, heterocycle, carbocycle, and a C1-10 alkyl chain optionally containing a carbon-carbon multiple bond or a carbon-hetero multiple bond wherein one or more carbon atoms are optionally independently replaced with oxygen, sulphur, SO, SO2, NR′, carbocycle or heterocycle; and R′ and R″ each are independently selected from alkyl, cycloalkyl, aryl, and heterocycle. |
