| 发明名称 | Morphine formulations | ||
| 摘要 | Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations. | ||
| 申请公布号 | US9192608(B2) | 申请公布日期 | 2015.11.24 |
| 申请号 | US201514715277 | 申请日期 | 2015.05.18 |
| 申请人 | BECTON DICKINSON FRANCE S.A.S. | 发明人 | Cuine Alain;Hoarau Didier;Romain Pauline |
| 分类号 | A61K31/44;A61K31/485;A01N43/42;A61K38/00;A61P25/04;A61K9/00;A61K47/02;A61K47/24;A61K47/12 | 主分类号 | A61K31/44 |
| 代理机构 | Wilson Sonsini Goodrich & Rosati | 代理人 | Wilson Sonsini Goodrich & Rosati |
| 主权项 | 1. A method of reducing pain in a subject, comprising: administering to the subject an injectable pharmaceutical formulation comprising per mL (a) from about 2 mg to about 10 mg of morphine sulfate or a hydrate thereof; (b) sodium chloride; (c) a buffering agent in an amount which provides a molar ratio of morphine sulfate to the buffering agent from about 0.4 to about 1.3 and is in an amount sufficient to provide a pH of 5 to the formulation; (d) disodium edetate dihydrate; (e) calcium chloride dihydrate; and (f) water for injection. | ||
| 地址 | Le Pont de Claix FR | ||