发明名称 |
METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF ROSUVASTATIN AND THIOCTIC ACID IN HYPOOESTROGEN-L-NAME-INDUCED NICTIC OXIDE DEFICIENCY |
摘要 |
FIELD: medicine.SUBSTANCE: method involves simulating a dysfunction by performing a bilateral ovariectomy in Wistar male rats. On the 43rd postoperative days, L-nitro-arginine-methyl ester (L-NAME) is administered intragastrically in a dose of 25 mg/kg daily during 7 days. The induced dysfunction is corrected by daily intragastric administration of Rosuvastatin 0.85 mg/kg and thioctic acid 50 mg/kg during 7 days concurring with the administration of L-NAME into the rats.EFFECT: method provides activating the correction of the endothelial dysfunction in hypooestrogenemia.1 tbl, 1 ex |
申请公布号 |
RU2568365(C1) |
申请公布日期 |
2015.11.20 |
申请号 |
RU20140132712 |
申请日期 |
2014.08.08 |
申请人 |
FEDERALNOE GOSUDARSTVENNOE AVTONOMNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO PROFESSIONALNOGO OBRAZOVANIYA "BELGORODSKIJ NATSIONALNYJ ISSLEDOVATELSKIJ UNIVERSITET" (NIU "BELGU") |
发明人 |
POKROVSKIJ MIKHAIL VLADIMIROVICH;MOLCHANOVA OLGA VIKTOROVNA;KOCHKAROV VLADIMIR ISKHAKOVICH;ARUSTAMOVA ANNA ALEKSANDROVNA;KOROKIN MIKHAIL VIKTOROVICH;GUDYREV OLEG SERGEEVICH;YAKUSHEV VLADIMIR IVANOVICH;SHABELNIKOVA ANNA SERGEEVNA;KOROKINA LILIYA VIKTOROVNA;POKROVSKAYA TATYANA GRIGOREVNA |
分类号 |
G09B23/28;A61K31/381;A61K31/495;A61P9/08 |
主分类号 |
G09B23/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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