| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a composition for producing viscoelastic crosslinked hyaluronic acid. The composition for producing crosslinked hyaluronic acid contains alkaline aqueous solution of hyaluronic acid with concentration of 15-25 wt % and a crosslinking agent and has a mechanical loss coefficient (Tan) ? of 0.5-1.5 at a frequency of 0.02-1 Hz. The method of producing crosslinked hyaluronic acid includes producing hyaluronic acid by crosslinking said composition and obtaining a suspension of crosslinked hyaluronic acid by crushing crosslinked hyaluronic acid, washing with a salt solution, swelling and grinding the crosslinked hyaluronic acid.EFFECT: invention enables to obtain crosslinked hyaluronic acid with acceptable viscoelastic properties and enzyme resistance.6 cl, 2 dwg, 1 tbl, 6 ex |
