发明名称 |
FRAMEWORK-SHUFFLING OF ANTIBODIES |
摘要 |
<p>The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies inmmunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The invention also provides method of producing improved humanized antibodies. The present invention also provides antibodies produced by the methods of the invention.</p> |
申请公布号 |
AU2013204018(C1) |
申请公布日期 |
2015.11.19 |
申请号 |
AU20130204018 |
申请日期 |
2013.04.11 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
WU, HERREN;DALL'ACQUA, WILLIAM;DAMSCHRODER, MELISSA |
分类号 |
C12N15/87;C12P21/08 |
主分类号 |
C12N15/87 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|