| 发明名称 |
METABOLOMIC PROFILING DEFINES ONCOGENES DRIVING PROSTATE TUMORS |
| 摘要 |
The invention provides methods and products to identify metabolic status of Akt1 and Myc in tumors, and to treat cancer. The method comprises performing an assay to measure a profile of metabolites in a prostate tumor sample obtained from a subject, wherein the metabolites are differentially produced in prostate tumors with high Akt1 expression versus prostate tumors with high Myc expression; and comparing, with at least one processor, the profile of metabolites with an appropriate reference profile of the metabolites to assign an Akt1 and Myc metabolic status to the sample based on results of the comparison. |
| 申请公布号 |
US2015330984(A1) |
申请公布日期 |
2015.11.19 |
| 申请号 |
US201314649045 |
申请日期 |
2013.12.06 |
| 申请人 |
Dana-Farber Cancer Institute, Inc. |
发明人 |
Loda Massimo;Priolo Carmen;Pyne Saumyadipta |
| 分类号 |
G01N33/574;C12Q1/68 |
主分类号 |
G01N33/574 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method to identify Akt1 and Myc status in a prostate tumor comprising:
performing an assay to measure a profile of metabolites in a prostate tumor sample obtained from a subject, wherein the metabolites are differentially produced in prostate tumors with high Akt1 expression versus prostate tumors with high Myc expression; and comparing, with at least one processor, the profile of metabolites with an appropriate reference profile of the metabolites to assign an Akt1 and Myc status to the sample based on results of the comparison. |
| 地址 |
Boston MA US |
