METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES

摘要

Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)

主权项

1. A method of treating pain or eliciting an analgesic effect in an individual, comprising administering an effective amount of at least one anti-human NGF antibody or fragment thereof, wherein the anti-NGF antibody is selected from Ab1, Ab2, Ab5, Ab6, Ab7, Ab8, Ab9, Ab10, Ab11, Ab12, Ab13, Ab14, Ab17, Ab18, Ab19, Ab20, or Ab21, or an antibody or antibody fragment that competes with any of the foregoing antibodies, an antibody or antibody fragment that binds to the same or overlapping epitope as any of the foregoing antibodies or an anti-human NGF antibody or antibody fragment comprising the same CDRs as any of said anti-human NGF antibodies or antibody fragments.