| 摘要 |
<p>The radionuclide 43Sc is produced according to the present invention at commercially significant yields and at specific activities and radionuclidic purities which are suitable for use in radiodiagnostic agents such as Positron Emission Tomography imaging agents. In the method and system of the present invention, a solid target having an isotopically enriched target layer prepared on an inert substrate is positioned in a specially designed target holder and irradiated with a charged-particle beam of protons or deuterons. The beam is generated using an accelerator such as a biomedical cyclotron at energies ranging from 3 to about 22 MeV. The present invention comprises the use of three different nuclear reactions: a) irradiation of enriched 43Ca targets with protons to generate the radionuclide 43Scin the nuclear reaction 43Ca (p,n)43Sc, b) irradiation of enriched 42Ca targets with deuterons to generate the radionuclide 43Sc in the nuclear reaction 42Ca(d,n)43Sc, and c) irradiation of enriched 46Ti targets with protons to generate the radionuclide 43Sc in the nuclear reaction 46Ti (p,a) 43Sc.</p> |
