SINGLE CHAIN VARIABLE FRAGMENT (SCFV) ELONGATION MUTANTS

摘要

The present invention relates to the provision of single chain variable fragment (scFv) elongation mutants. In addition, the present invention relates to a pharmaceutical composition comprising said scFv elongation mutants, as well as a nucleotide sequence encoding said scFv elongation mutants, a vector comprising said nucleotide sequence or a host cell expressing said nucleotide sequence. Particular embodiments relate to elongation mutants of the scFv-h3D6 which is derived from monoclonal antibody mAb-h3D6 (bapineuzumab). It is further disclosed a method of prevention or treatment of a patient in risk of suffering, or already diagnosted as suffering, Alzheimer disease that comprises the administration to said patient of an effective amount of the scFv elongation mutants of scFv-h3D6.