发明名称 |
VIRUS LIKE VESICLES (VLVs) BASED VACCINES TO PREVENT OR TREAT CHRONIC HEPATITIS B VIRUS (HBV) INFECTION |
摘要 |
The present invention relates to the discovery of compositions and methods for therapeutic immunization for treatment of chronic hepatitis B. Methods of the invention include a method generating an evolved high titer hybrid-hepatitis B virus (HBV) vector, methods of treating and/or preventing HBV, and methods of inducing a memory T and B cell immune response against HBV infection in a subject administered the VLV composition produced thereby. Furthermore, the invention encompasses a pharmaceutical composition for vaccinating a subject to protect the subject against infection with HBV. |
申请公布号 |
WO2015175380(A1) |
申请公布日期 |
2015.11.19 |
申请号 |
WO2015US30100 |
申请日期 |
2015.05.11 |
申请人 |
YALE UNIVERSITY |
发明人 |
ROBEK, MICHAEL;ROSE, JOHN;REYNOLDS, TRACY |
分类号 |
C12N15/63 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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