| 主权项 |
1. A compound of Formula I:or a pharmaceutically acceptable salt, or stereoisomer thereof; wherein
“-----” represents a single or double bond; A is CR8aR9b, NR9, or O; wherein R8a, R8b and R9 are each independently hydrogen or C1-6alkyl; L is *—C(O)NR10— or *—C(O)O—, wherein “*” represents the point of attachment of L to the bicyclic ring containing A, and R10 is hydrogen or C1-6alkyl; R0 is selected from hydrogen and C1-6alkyl; R1 is selected from halo, cyano, —C(O)R11, —C(O)NR12aR12b, —C(O)ONR12aR12b, 5 and 6-membered heterocycloalkyl, 5- and 6-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein
R11 is hydrogen or C1-6alkyl;R12a and R12b are each independently hydrogen or C1-6alkyl;the heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R1 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6haloalkyl, —C(O)R13, —C(O)OR13, —NR14aR14b, 5- and 6-membered heterocycloalkyl, phenyl, and 5- and 6-membered heteroaryl; wherein
R13 is selected from hydrogen, C1-6alkyl, C1-6haloalkyl, amino, and C1-6alkylamino;R14a and R14b are each independently selected from hydrogen, C1-6alkyl, —C(O)R15, —C(O)OR15, and —S(O)2R15, wherein R15 is hydrogen or C1-6alkyl; andthe heterocycloalkyl, phenyl or heteroaryl substituent of R1 is further substituted by 1 to 2 substituents independently selected from halo, C1-6alkyl, C1-6haloalkyl, and hydroxy; R3 is selected from C1-6alkyl, C1-6haloalkyl, 3- to 6-membered cycloalkyl, 4- to 7-membered heterocycloalkyl, 5- to 10-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein
the cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R3 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy, —C(O)R16, —C(O)OR16, —S(O)2R16, 5 and 6 membered heterocycloalkyl, and pheny; wherein
R16 is hydrogen or C1-6alkyl;the phenyl or heterocycloalkyl substituent of R3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, and C1-6haloalkyl; and R2 and R4 are each hydrogen or C1-6alkyl; or R2 and R4 taken together form a cyclopropyl ring fused to the bicyclic ring containing A; or R2 and R4 taken together form a bond producing a double bond between the two carbons to which R2 and R4 are attached; and R5 is hydrogen or C1-6alkyl, or R5 and R10 taken with the atoms to which they are linked form a 5- or 6-membered ring fused to the bicyclic ring containing A; and R6 and R7 are each hydrogen or C1-6alkyl; or R6 and R7 taken together form a bond producing a double bond between the two carbons to which R6 and R7 are attached. |
