COMPOSITIONS FOR BINDING AND SEPARATING OF PROTEINS

摘要

A composition for binding and separating proteins characterized by the general formula (II) wherein R1 is a hydrophobic group of small size, preferably hydrogen, or C1C8 straight chain or branched alkyl, or C2-C8 straight chain or branched alkenyl or alkynyl, C6-G8 aryl or aralkyl or cycloalkyl group; or alkoxy group, preferably methoxy or ethoxy group; or acyloxy group, preferably acetyloxy group; or chlorine, R2 is R1 or a hydrophobic group of small size, preferably hydrogen, or C1C8 straight chain or branched alkyl, or C2-C8 straight chain or branched alkenyl or alkynyl, C6-C8 aryl or aralkyl or cycloalkyl group; or alkoxy group, preferably methoxy- or ethoxy group; or acyloxy group, preferably acetyloxy group; or chlorine different form R1, R3 is R2 or a non-reactive group which contains straight chain, branched or cyclic structures formed by 2 - 30 covalently connected carbon, oxygen, sulfur, fluorine, chlorine, bromine or iodine atoms, symbol = represents one, two or three covalent single bonds between the Si atoms and the surface of the support, in case of one covalent bond, two of the R1- R3 groups are attached to the given Si atom; in case of two covalent bonds, one of the R1- R3 groups is attached to the given Si atom; in case of three covalent bonds, none of the groups R1 - R3 are attached to the given Si atom, A is an atom or group of atoms containing a non-bonding pair of electrons, preferably NH, NR3, S, O, L is a straight, branched or cyclic structure connecting Si atoms and the A moiety comprising 2 - 22 carbon, sulfur or nitrogen atoms covalently connected to each other, x is a number and 0 >x> 1, m is an integer and m = 0, 1 or 2.