Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

摘要

Provided herein are Aminopurine Compounds having the following structure:;wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

主权项

1. A compound having the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is substituted or unsubstituted C3-10heterocycle; R2 is cyclohexyl substituted with one or more hydroxyl, cyano, tetrazolyl, triazolyl or imidazolyl groups; and R3 is aryl substituted with one or more halogens.