发明名称 1- OR 2-SUBSTITUTED ARTEMISININ DERIVATIVES FOR INCREASING THE IN VIVO BIOLOGICAL ACTIVITY OF BIOLOGICALLY ACTIVE COMPOUNDS
摘要 <p>The present invention relates to compounds with an increased in vivo biological activity, and especially an increased pharmaceutical activity, such as an anti-nematodal or antifungal activity, an immunosuppresive activity, a metabolism influencing activity and/or an anti-cancer activity. Specifically, the present invention relates to compound comprising an artemisinin derivative according to the general formula (I) covalently linked at the 1 or the 2 position to a compound with a biological activity thereby increasing the biological activity of said compound or a pharmaceutically acceptable salt thereof.</p>
申请公布号 CA2698973(C) 申请公布日期 2015.11.17
申请号 CA20082698973 申请日期 2008.09.10
申请人 DAFRA PHARMA N.V. 发明人 JANSEN, FRANS HERWIG;SOOMRO, SHAHID AHMED
分类号 C07D493/20;A61K31/365;A61P33/06 主分类号 C07D493/20
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