发明名称 Internal optical spectroscope and method for real time in-situ diagnosis in living cells
摘要 The present application relates to an internal optical spectroscope comprising: a needle sleeve insertable into and removable from targeted living tissue; a shaft housed by the needle sleeve including at least one v-shaped trough including an aft side and a next-to-aft side; a light source comprising variable light wave lengths of both visible and near infrared light; at least one light transmission fiber comprising a transmitting end; at least one light detector fiber comprising a receptive end; and data processor. The present application also relates to a method of performing an optical biopsy in situ.
申请公布号 US9186064(B2) 申请公布日期 2015.11.17
申请号 US201313970665 申请日期 2013.08.20
申请人 The United States of America as represented by the Secretary of the Army 发明人 Shumate Daniel Lee;Ruffin Paul B;Davenport Wayne
分类号 A61B6/00;A61B5/00;A61B10/02 主分类号 A61B6/00
代理机构 代理人 Haymond W. B.
主权项 1. An internal optical spectroscope comprising: a) a needle sleeve comprising a shaft, the needle sleeve being insertable into and removable from targeted living tissue; b) the shaft housed by the needle sleeve, the shaft comprising a pointed insertion end and at least one v-shaped trough including an aft side and a next-to-aft side, the shaft is capable of being at least partially pushed out of the needle sleeve and into the targeted living tissue when the needle sleeve is already in the targeted living tissue, and the shaft also is capable of being pulled out of the targeted living tissue and back into the needle sleeve when the needle sleeve is in the targeted living tissue, the at least one v-shaped trough in the shaft being capable of holding at least one fold of the targeted living tissue but not removing or substantially damaging any of the targeted living tissue while the shaft is being pushed out of the needle sleeve into the targeted living tissue, while the shaft is in the targeted living tissue, or while the shaft is be removed from the targeted living tissue; wherein the shaft comprises screw threads extending spirally along the outside surface of the shaft, with the v-shaped trough formed between aft and next-to-aft threads, a screw shaft is capable of being at least partially pushed out of the needle sleeve and screwed into the targeted living tissue when the needle sleeve is in the targeted living tissue, and the screw shaft also is capable of being unscrewed out of the targeted living tissue and back into the needle sleeve when the needle sleeve is in the targeted living tissue c) a light source comprising variable light wave lengths of both visible and near infrared light; d) at least one light transmission fiber comprising a transmitting end, the at least one light transmission fiber being connected to the light source and stretching along a length of the shaft, the light source being capable of sending light through the at least one light transmission fiber with the transmitting end attached to the next-to-aft side or the aft side of the v-shaped trough, so that the light escapes directly out of the transmitting end into the v-shaped trough from the next-to-aft side or the aft side of the v-shaped trough, the light traveling from the transmitting end across the v-shaped trough, the light being capable of penetrating through the at least one fold of tissue held in the v-shaped trough and causing the at least one fold of tissue to fluoresce light when the at least one fold of tissue is held in the v-shaped trough; e) at least one light detector fiber comprising a receptive end, the receptive end being positioned on an opposite side of the v-shaped trough from the side of the transmitting end, the at least one light detector fiber stretching from the receptive end along the shaft to a data processor, the receptive end being capable of receiving fluoresced light from the at least one fold of fluoresced tissue and transmitting an optical signal to the data processor; and f) the data processor.
地址 Washington DC US