Sustained release formulation of nalbuphine

摘要

Sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof to treat patients suffering from pain are provided.

主权项

1. A sustained release oral solid dosage formulation comprising nalbuphine or a pharmaceutically acceptable salt thereof homogenously dispersed in a sustained release matrix delivery system, wherein the dosage form exhibits an in vitro dissolution of about 15% to about 50% by weight nalbuphine after 1 hour and at least about 65.3% by weight nalbuphine after 8 hours, and which provides a controlled release of nalbuphine over at least about 8 hours, in the form of a tablet.