Nitric oxide-releasing nanorods and their methods of use

摘要

In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.

主权项

1. A nitric oxide-releasing nanorod comprising,
i. a silane, and ii. a functionalized mono, di or trialkoxysilane, wherein said functionalized mono, di or trialkoxysilane comprises a NO-donor molecule; wherein said nanorod has an aspect ratio of at least 1 and a [NO]max in a range of about 10 ppb/mg to about 16,000 ppb/mg.