N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases

摘要

The invention relates to N-substituted nicotinamide compounds of Formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of Formula I, and methods for the treatment of migraine and neurologic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, migraine, Post Herpetic Neuralgia, Acute and Chronic Pain, Alzheimer's disease, Creutzfeld Disease, familial amyloid polyneuropathy, parkinson's disease, fibromyalgia syndrome.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer, or stereoisomer thereof, wherein: R1 represents R2 represents NULL, R3 represents each n is independently 1, 2, 3, 4 or 5; each a is independently 2, 3 or 7; each b is independently 3, 5 or 6; each e is independently 1, 2 or 6; and each c and each d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3.